|Stochastic Systems Group|
Discussion on genomics
In this informal discussion, some solutions, some problems, and some questions about genomics will be overviewed at a high level. The central dogma of molecular biology is that information flows from DNA to RNA to protein, regulated by a network of interactions and signaling pathways. The process of molecular evolution comes about due to random mutation and natural selection. Much of life can be understood through these two elements separately and jointly. Problems such as gene sequencing, multiple sequence alignment, phylogenetic inference, regulatory motif discovery, and gene regulatory network inference; approaches for their solution, especially probabilistically based ones; and some open questions that arise, such as possibilities for improved probabilistic models, will be mentioned.
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